韩国人特有的基因突变
有大量与精神障碍相关的基因

此页面是通过机器翻译从英文到中文创建的。如果你会看英文，请用英文阅读

用英文写的

人的个性（即气质和性格）是与心理健康相关的复杂特征，受遗传和环境因素的影响。尽管在过去几十年中做出了努力，但它的遗传背景才刚刚开始被发现。 从明确的数据事实1来看，韩国人可能“疯了”。下面的列表是 韩国人特异性突变列表的一部分
基因列表来自下面的论文

Whole genome sequencing of 35 individuals provides insights into the genetic architecture of Korean population
Wenqian Zhang et al.
Published: 21 October 2014 in BMC Bioinformatics
additional_file_7 xlsx


请记住，上述论文实际上是由 FDA（美国食品和药物管理局）撰写的，正式否认了这一事实。

上述论文未投稿至 Nature 或 Science 等著名科学期刊，但该论文于 2014 年 3 月在美国奥克兰举行的学术会议上发表。

上述论文的作者如下，除罗恒为FDA研究员或编程工程师外，其余作者均为FDA研究员或编程工程师。 （上述论文发表时，罗恒是美国阿肯色大学的研究生，目前在FDA做研究员）

Wenqian Zhang(FDA)
Joe Meehan(FDA, Ph.D.)
Zhenqiang Su(FDA)
Hui Wen Ng(FDA)
Mao Shu(FDA)
Heng Luo(graduate student )
Weigong Ge(FDA)
Roger Perkins
Weida Tong(FDA, Ph.D.)
Huixiao Hong(FDA, Ph.D.)

[引用自上述人口遗传学论文]
内容完全由作者负责，并不一定代表美国食品和药物管理局、国家研究资源中心或美国国立卫生研究院的官方观点。

披露
本文中的调查结果和结论尚未由美国食品和药物管理局 (FDA) 正式传播，不应被解释为代表 FDA 的决定或政策。

声明
本文的出版费用由美国政府资助。



从 SNV-1 到精神障碍/精神特征

1. 请不要误会下面的列表都是正确的，因为其他论文可能会显示不同或相反的结果。如果您知道否认结果的论文，请通知我

2. 请仔细思考下面列出的异常结果。令我遗憾的是下面的遗传学论文显示“疯狂的韩国人”

1. 毫无疑问，绝大多数超过 350 的 SNV-1 与精神疾病、人格障碍和人类人格有关， 换句话说，尽管地理上相近，但韩国人的心理特征与中国人和日本人完全不同。

2.不用说，重要的是不要忘记遗传病理学的论文在很多情况下包含很多有争议和有争议的结果， 所以请记住上述论文中提出的结果不一定正确的假设。 因此，多篇论文必须表明精神疾病和基因之间存在遗传关联。

3. 韩国学历高、人口多，63项国际科学奖全无获得者 （详细数据在这里），这个事实与上面的列表完全吻合。

PRIM2 和 snoU13 基因

可以肯定的是，与重度抑郁症有关的失眠症在韩国蔓延，而韩式的失眠症是由PRIM2和snoU13基因引起的。

CSMD1,CNTNAP2,OR4C5 和别的

CSMD1 gene
# of SNVs in SNV-1=1786
# of nsSNVs in SNV-1=1
# of SNVs in SNV-35=1
# of SNVs in nsSNV-35=0

OR4C5 gene
# of SNVs in SNV-1=155
# of nsSNVs in SNV-1=21
# of SNVs in SNV-35=49
# of SNVs in nsSNV-35=11
from additional_file_7 xlsx

1.韩式精神分裂症存在于韩国人这一事实是无可争辩的。 然而，据我所知，没有任何论文表明韩国精神分裂症患者的特有症状。

2.请不要误解，韩国人的精神分裂症患病率低于其他民族，事实恰恰相反。 与白人和黑人相比，韩国人、日本人和中国人的精神分裂症患病率较低。

PDE4DIP and ZNF717 gene

这些基因可能是决定韩国人性格（即气质和性格）的关键基因。

PDE4DIP gene
# of SNVs in SNV-1=1374
# of nsSNVs in SNV-1=138
# of SNVs in SNV-35=14
# of SNVs in nsSNV-35=3


ZNF717 gene
# of SNVs in SNV-1=856
# of nsSNVs in SNV-1=28
# of SNVs in SNV-35=3
# of SNVs in nsSNV-35=0
from additional_file_7 xlsx



从智力相关基因列表到SNV-1

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Jeanne E Savage et al.
Published online 2018 Nature genetics

据我所知，上述论文是最全面的与智力相关的基因论文，补充材料包括智力基因列表。
与上述论文和SNV-1比较的结果

compare.xlsx
ratio of SNV-1 in intelligence related gene list
compare2.xlsx
ratio of SNV-1/ns in intelligence related gene list
compare2.xlsx
validation of SNV-1 ratio

令人惊讶的是，几乎所有的SNV-1都与智力有关，具体来说，上述论文指定的507个与智力相关的基因中有496个基因（97.8%）是SNV-1。 （SNV-1=仅韩国人变种=在 35 名韩国人中的至少一人中检测到但未包含在 HapMap 或 1KGP 中的 SNV）

也许，你会认为韩国人的智慧与中国人和日本人的智慧并没有什么不同。 但是，毫无疑问，遗传学论文清楚地表明，韩国人在智力上与中国人和日本人完全不同。

尽管地理上接近，为什么会发生这种奇怪的现象？
13世纪成吉思汗父子入侵朝鲜半岛发生瓶颈效应。
我推断朝鲜半岛的人口在 13 世纪下降了 85% 到 90%。（请阅读本文，使用机器翻译工具。 中国研究人员估计，邻近的中国辽宁省的人口在同一时期也减少了 90%。）

或许，这句话将在未来的三年内传遍全球。

你和韩国人一样疯狂。

---

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[cited from the above paper] Abstract
Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap with intelligence (IQ), reasoning, and working memory in a twin and sibling sample aged 15-29 years (N = 787). Further, in an exploratory search for genetic loci contributing to RC, we examined associated genetic markers and genes in our Discovery sample and selected loci for replication in four independent samples (ALSPAC, LBC1936, NTR, NCNG), followed by meta-analysis (N>6500) at the single marker level. Twin modelling showed RC is highly heritable (67%), has considerable genetic overlap with IQ (59%), and is a major component of genetic covariation between reasoning and working memory (72%). At the molecular level, we found preliminary support for four single-marker loci (one in the gene DGKB), and at a gene-based level for the NPS gene, having influence on cognition. These results indicate that genetic sources influencing relational processing are a key component of the genetic architecture of broader cognitive abilities. Further, they suggest a genetic cascade, whereby genetic factors influencing capacity limitation in relational processing have a flow-on effect to more complex cognitive traits, including reasoning and working memory, and ultimately, IQ.

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[cited from the above paper] Twenty-two of the DMRs identified were within the major histocompatibility complex (MHC; Fig. 3), which has been implicated in the pathogenesis of SZ through a large-scale GWAS.16 In addition, we identified DMRs within two additional genes (IGSF9B, CNTN4) that showed genome-wide association with SZ in the same study.
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[cited]
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paper[90]
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[cited from the above paper]
OR4C5 is a gene predicted by GDI to be highly damaging.

[notes]
# of SNVs in SNV-1/ns is 21.
"# of SNVs in SNV-35/ns" is 11.

paper[91]
Identification of genes and gene pathways associated with major depressive disorder by integrative brain analysis of rat and human prefrontal cortex transcriptomes
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Nature Published: 03 March 2015


paper[92]
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September 2012

paper[93]
Whole Exome Sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
Suhas Ganesh et al.
November 5, 2021

paper[94]
Differences in human and chimpanzee gene expression patterns define an evolving network of transcription factors in brain
Katja Nowick et al.
Published online 2009 Dec 10



paper[95]
An alternative splicing hypothesis for neuropathology of schizophrenia: evidence from studies on historical candidate genes and multi-omics data
Chu-Yi Zhang et al.
Nature Published: 08 March 2021



paper[96]
Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases
Tharani Sundararajan et al.
Published online 2017 Oct 13