Supplementary Table S7: Detailed information of top pathways enriched in non-synonymous Korean only SNVs (SNV-1/ns and SNV-35/ns)
Korean only SNVs Order  PathwayName #Gene statistics
(C: the number of reference genes in the category; O: the number of genes in the gene set and also in the category; E: the expected number in the category; R: ratio of enrichment; rawP: p value from hypergeometric test; adjP: p value adjusted by the multiple test adjustment; )		 EntrezGene
SNV-1 1 Metabolic pathways 295 C=1130;O=295;E=135.54;R=2.18;rawP=1.34e-39;adjP=2.61e-37 2678, 2548, 32, 317749, 4942, 3631, 387787, 116285, 4124, 348158, 31, 2731, 6610, 2954, 124454, 4717, 10026, 7378, 6609, 51196, 1553, 8972, 1638, 3340, 119548, 7263, 5167, 2203, 15, 1577, 211, 23417, 91373, 5214, 1737, 51084, 3636, 1962, 2592, 171568, 1609, 55301, 2683, 100137049, 151531, 8818, 26301, 471, 218, 10975, 1608, 131, 1558, 4860, 51604, 5558, 594, 5422, 314, 9489, 2194, 8630, 10901, 4716, 160851, 847, 2058, 22978, 55750, 50484, 5859, 5332, 245972, 93034, 85365, 55627, 10380, 37, 3073, 1717, 270, 7498, 9060, 5313, 5048, 1555, 5409, 6389, 1585, 5331, 246, 65263, 64132, 22845, 1607, 55821, 55650, 1787, 189, 535, 1056, 2585, 4701, 54675, 80270, 6392, 10170, 51181, 221223, 5033, 154141, 84076, 229, 64579, 7363, 4719, 89869, 84245, 875, 11019, 506, 6120, 2937, 5742, 9331, 6470, 58510, 56895, 7384, 5091, 36, 51, 3098, 411, 125061, 1593, 11285, 4598, 56922, 7841, 146664, 10423, 522, 2752, 525, 23475, 1621, 272, 95, 55902, 10449, 7385, 3032, 1789, 50617, 3373, 231, 55703, 64600, 3704, 6241, 56267, 339221, 2595, 25902, 54579, 84720, 1743, 275, 55300, 3141, 8974, 23530, 80347, 5049, 9942, 8639, 435, 55224, 22856, 8659, 5211, 4708, 8871, 94005, 5431, 50487, 4522, 123745, 3612, 26289, 10201, 1066, 7108, 25834, 144193, 26035, 5226, 3423, 251, 1594, 5980, 8529, 1548, 23498, 283208, 26290, 5337, 216, 4843, 84620, 284541, 33, 9468, 4191, 54947, 5283, 83549, 9615, 151056, 2132, 23761, 8277, 1757, 55229, 3948, 5336, 2805, 6185, 8693, 5169, 168391, 84274, 25796, 5333, 5538, 4597, 54988, 48, 6677, 4967, 27010, 5743, 3938, 7915, 8372, 5050, 10312, 1544, 5288, 5740, 10720, 8854, 4128, 1716, 5723, 3067, 29958, 54658, 55191, 8760, 8525, 55276, 81616, 8681, 3034, 26007, 64816, 5297, 51478, 27090, 26330, 2618, 2588, 54578, 6472, 4728, 84172, 5106, 3101, 130, 150763, 54802, 55753, 27124, 5498, 2572, 10588, 55790, 3614, 38, 2720, 34, 51179, 8310
2 ECM-receptor interaction 47 C=85;O=47;E=10.20;R=4.61;rawP=8.10e-22;adjP=7.90e-20 2335, 3339, 8516, 3655, 10319, 7059, 284217, 3693, 3371, 1293, 131873, 7057, 3914, 3909, 2811, 3696, 1289, 3690, 3913, 1282, 22801, 3672, 960, 3680, 1311, 3910, 3695, 1292, 1290, 7143, 3915, 1286, 1277, 9900, 5649, 3908, 1605, 1101, 3679, 3673, 3912, 7450, 51206, 3691, 1288, 3911, 3381
3 Focal adhesion 72 C=200;O=72;E=23.99;R=3.00;rawP=1.31e-18;adjP=8.52e-17 8516, 1793, 5156, 3371, 2317, 131873, 3909, 6464, 1289, 3690, 1282, 22801, 5293, 4233, 83660, 1311, 4636, 5159, 3910, 3695, 1292, 1290, 207, 1277, 394, 93408, 2316, 3908, 2909, 3673, 4638, 3912, 6093, 3911, 85366, 673, 2335, 4659, 3655, 10319, 7059, 3693, 284217, 6714, 1293, 3914, 7057, 824, 3696, 5601, 3913, 3680, 3672, 858, 7423, 7424, 5170, 10451, 5829, 7143, 3915, 1286, 5649, 3611, 9564, 1956, 1101, 3679, 7450, 3691, 1288, 3381
4 Lysosome 43 C=121;O=43;E=14.51;R=2.96;rawP=1.67e-11;adjP=8.14e-10 2548, 8218, 768239, 256471, 1508, 23163, 4125, 23062, 23457, 8120, 22901, 2588, 50617, 3373, 5641, 1212, 9741, 1511, 51172, 3482, 11154, 6556, 5538, 1510, 6609, 535, 1777, 4891, 26503, 1203, 3988, 4864, 3423, 950, 1497, 10312, 1213, 23659, 2720, 245972, 5660, 411, 3073
5 Calcium signaling pathway 53 C=177;O=53;E=21.23;R=2.50;rawP=1.43e-10;adjP=5.58e-09 5724, 196883, 89869, 6261, 489, 5024, 8912, 6543, 5156, 5566, 5331, 83447, 2911, 775, 2905, 9127, 5336, 115, 109, 779, 2065, 2903, 148, 1131, 5159, 8913, 5333, 777, 773, 5257, 107, 51196, 6262, 3710, 487, 3360, 1956, 9630, 185, 146, 816, 6263, 3357, 4638, 3708, 5332, 2185, 774, 886, 4843, 5026, 85366, 493
6 Pathways in cancer 79 C=326;O=79;E=39.10;R=2.02;rawP=6.36e-10;adjP=2.07e-08 2475, 10928, 6256, 7157, 5156, 637, 1441, 23604, 1387, 4193, 3909, 999, 4790, 5336, 1282, 5293, 4233, 5159, 3910, 207, 862, 1630, 1019, 868, 5727, 3908, 2260, 5743, 675, 7185, 8312, 3673, 3912, 8900, 7188, 405, 3911, 4318, 673, 2335, 3728, 3655, 7186, 1495, 10319, 5900, 2113, 284217, 3914, 2737, 4313, 5601, 1612, 3913, 3320, 89780, 6774, 2956, 7423, 613, 5915, 7424, 3915, 1286, 354, 1956, 7175, 8031, 3091, 7849, 3569, 5371, 652, 5337, 1288, 1017, 4843, 6789, 1436
7 Purine metabolism 48 C=162;O=48;E=19.43;R=2.47;rawP=1.52e-09;adjP=4.23e-08 196883, 9060, 55276, 5313, 4882, 171568, 9615, 5139, 272, 2618, 5147, 3000, 471, 115, 109, 112, 55703, 5144, 84172, 55821, 5431, 5169, 26289, 5558, 954, 10201, 4860, 3704, 5422, 107, 6241, 2984, 27115, 5138, 318, 50940, 22978, 5167, 50484, 2983, 3614, 93034, 5158, 1716, 55811, 87178, 270, 7498
8 Pancreatic secretion 35 C=101;O=35;E=12.11;R=2.89;rawP=2.66e-09;adjP=6.48e-08 196883, 489, 8681, 5646, 6344, 1080, 100137049, 1360, 5331, 5644, 115, 109, 112, 64600, 50487, 1131, 1179, 123745, 219931, 107, 6262, 1056, 3784, 3710, 487, 23436, 51032, 1811, 9635, 3708, 5332, 482, 22802, 886, 493
9 Dilated cardiomyopathy 32 C=90;O=32;E=10.80;R=2.96;rawP=6.11e-09;adjP=1.32e-07 7273, 196883, 1756, 8516, 3655, 5566, 3693, 3696, 775, 59284, 3690, 115, 109, 112, 22801, 779, 3672, 3680, 4625, 3695, 107, 6262, 3908, 6445, 93589, 1605, 4607, 3679, 3673, 4624, 3691, 781
10 Tight junction 40 C=132;O=40;E=15.83;R=2.53;rawP=1.68e-08;adjP=3.28e-07 4622, 57530, 154810, 8735, 1495, 1457, 4627, 64398, 7082, 4628, 6714, 9073, 4619, 5010, 9414, 23136, 1364, 8777, 22989, 79784, 58494, 4636, 4620, 4625, 207, 2036, 1019, 93408, 57644, 260425, 10207, 4629, 2035, 4301, 27134, 60412, 4626, 5590, 4624, 9863
SNV-35 1 Vibrio cholerae infection 2 C=54;O=2;E=0.04;R=55.08;rawP=0.0006;adjP=0.0018 4583, 1080
2 Axon guidance 2 C=129;O=2;E=0.09;R=23.06;rawP=0.0034;adjP=0.0051 6093, 6092
3 Olfactory transduction 2 C=388;O=2;E=0.26;R=7.67;rawP=0.0279;adjP=0.0279 256144, 390174