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When spring is in the air in Japan and iron storm by Russia were starting to cover Ukraine, the author has released several articles on this web site, basing on population genetics papers which clearly indicate the ineffable anomalies of Korean genetic architecture. It is at the heart of genetic research for an isolated and homogeneous ethnic population that analyzing of inherent variants and the frequency of the gene provides more information for promoting mental and physical health of the population. To my regret, figuratively speaking, I feel that Korean's gene indisputably are as if Satan's gene, considering that it is now feasible to obtain deep whole genome sequencing data. What if in the event that Koreans gene spread over the world, humankind shall be filled with lie and scam, like Korean peninsula.


Korean actress


United States Department of State do make a warning to young women's journeys to South Korea about sexual assault. Please strongly note that the United States don't make same warning to other countries (i.e. China, Japan etc.)



What is "family-destroying criminals"?



Stupid lie and scam by Koreans who lies all the time like breathing because of DNA  anomalies

Historical facts


Looking N.W. along a street in the native (old) Pusan, Korea 1904 year



White-robed pottery peddlers on the streets of Seoul, Korea 1906 year



Little Korean girls, of the middle class, in the northern suburbs of Seoul, Korea 1904 year
Could you understand ?
Please gaze red circle, and please remember that it's 1904=20th century !



1886 year? photographer name:Hayashi, Northwest entrance gate to Seoul, Korea


It nauseously are the most absurd lie and scam


Although I can't help but sneere at Koreans, however, Koreans would never accept historical facts like the above photos, neglecting the very obvious evidence, and there is no doubt whatever about "schizophrenic conviction" that Koreans exceedingly are excellent ethnic group next to ashkenage jews.

Monster DNA

Kikuzou Otani, the chief of the staff in the Japanese army stationed in Korea when Japan began to rule the Korean peninsula in 1906 after Russo-Japanese War, severely criticized The Koreans who want to contact him for seeking some benefits. And he wrote in his diary that The Koreans are "Monsters" who subsist in only the Korean peninsula.
According to Otani's diary, a great majority of The Koreans are congenital scammers who are seeking profits by vilifying and deceiving others including The Japanese. And his opininon was correct in the meaning that "The Koreans carry high percentages of non-silent variants In contrast with other ethnic groups and a great majyority of Korean only variants has relation to human spirits".

The Koreans undoubtedly are Monster from the viewpoint of population genetics according to the following various data and population genetics paper.


 

Please note that Koreans male keeps hitting his wife with keeping his composure and no rage in spite of son's violent crying.


Abstract

According to the following genetics papers, genetic structure of Koreans are very strange and unique in the following four points,

1.Koreans have high percentages of non-synonymous variants compared with other ethnic population (The Japanese, The chinese etc)



2.As opposed to the other ethnic population (The Japanese, The Chinese, etc.), variants which are inherent to Koreans extremely biased to the parts of Koreans.



3.MAF(minor allele frequency) clearly differs from the other ethnic population, includingthe Japanese, the Chinese, therefore, many genes of Koreans are under more strong negative selection pressure combined with high ratio of non-synonymous variants compared to the other ethnic population.



4. The overwhelming majority of variants which are inherent to Koreans have relation to mental diseases, personality disorders and human mentality. Please visit for details.





Strange phenomenon in South Korea

Total fertility rate in South Korea is aberrant !

2016
2017
2018
2019
2020
2021
2022
2023
1.17
1.05
0.98
0.92
0.84
0.81
0.78
0.72


South Korea continue to broke their own record over a past decade of low total fertility rate i.e.the average number of children born to a woman during her reproductive years, reflecting societal problems and completely abnormal university entrance exam in South Korea.

Although it's conundrum that why South Korea women doesn't want to has child, there could be no dispute that only competition in university entrance exam is fair competition in South Korea. Therefore, they must spend huge money for enrolling into prestigious university, and pupils in high school are forced to learning for long hours every day.

Please strongly keep in minds South Korea indicates tremendously low figure in total fertility rate, South Korea continue in "War-Time" but not "Peace-Time".

Korean Actress


Suicide rates is the highest in the world



A great majority of researchers in South Korea make a pretext of that old Koreans indicates high suicide rate compared with adorescen why suicide rate in South Korea is the heighest in the world.

However, in part due to deliberate focus on suicide rate, the essence that Koreans carry inherent variants about MDD(major depressive disease) ultimately shall be disappear.

It is complete and scientific fact and is beyond all doubts that the Koreans carry numerous brain-related variants inherent to the Koreans which might be the cause of Koreans specific mental disorder i.e "Hwabyung" , and please understand that it is never racism and taunts to Koreans.

The above two data clearly indicates that "Meta Natural Force" wants to exterminate Koreans DNA

Koreans who outwardly are Christians will insist and infuriate that it's sacrilege to "Meta Natural Force" or God ! But, the clear data can't lie !

Please note that "Meta Natural Force" means natural selection pressure for deletelious variants in population genetics, and The Koreans undoubtly carry high percentage deletelious variants compared with other ethnic groups like The Chinese, The Japanese.

[Cited from paper by FDA]
In contrast with the SNVs common to other populations in HapMap and 1KGP, the Korean only SNVs had high percentages of non-silent variants, emphasizing the unique roles of these Korean only SNVs in the Korean population.



A great majority of Koreans have a daydream that "we are an excellent ethnic group", therefore, Koreans explicitly show contemptuous attitudes that "stupid people like Southeast Asia's people should be obedient to excellent people like Koreans". As the natural result, Southeast Asia's people who frequently and dairy contact with Koreans hate Koreans. br clear="all">
Please awake and stand up Thailanders, Vietnamese and Filipino to devil's gene = Koreans gene !

Aberrant obsession to cosmetic surgery

I don't know cosmetic surgery expenditure of BTS members(BTS=Bangtan Boys), but it is beyond all doubts that BTS members did plastic surgery.

Cited from paper[1]

This article explores the unusually high levels of cosmetic surgery in South Korea – for both women and men.
South Korean’ alleged ‘obsession’ with cosmetic surgery regularly hits headlines both in Asia and the ‘West’ because of its reportedly high take-up rate by both women and men.
Cosmetic surgery and skin treatment clinics are now commonplacein urban shopping malls, viewed much like nail and beauty salons in the UK, and providing procedures such as laser removal ofblemishes to 'walk-in’ customers.





No winners of famous scientific prizes

There are no winners of all sixty-three famous scientific prizes in South Korea, despite of high education revel ratio and large population size.

  South Korea Japan Taiwan
prizes winner 0 at least over 220 at least over 11
population size 50M 125M 25M

To my knowledge, the Koreans utterly boaste and has groundless belief that "we are excellent ethnic groups next to Jews in the world " irrespective of the above fact, therefore, figuratively speaking, South Korea might be "huge mental hospital".
Please visit for details.

 


From population genetics paper

According to several population genetics papers, it is beyond all doubts that the genetic structure of Koreans is astonishingly unique and strange.

Koreans have high percentages of non-synonymous variants compared with other ethnic population (the Japanese, the chinese etc)

Cited from paper[10]
A subset of the nsSNPs showed remarkably high allele frequencies among the Koreans studied compared to other populations, including Europeans and west Africans represented in the HapMap project.

Cited from paper by FDA
In contrast with the SNVs common to other populations in HapMap and 1KGP, the Korean only SNVs had high percentages of non-silent variants, emphasizing the unique roles of these Korean only SNVs in the Korean population.

Cited from paper[5]
The portion of non-synonymous SNVs in the ‘1000GP rare’ class was more than twice what was observed in the other classes.
It is possible that these patterns are associated with purifying selection to rapidly remove deleterious alleles in the population

As opposed to the other ethnic population, variants which are inherent to Koreans extremely biased to the parts of Koreans.

Cited from paper by FDA
Figure 2b shows that nearly 60.59 % (735,271) of Korean only SNVs are observed in only one individual, while 1.04% (12,640) of Korean only SNVs are observed in all 35 individuals. Therefore, we rationally conjectured that Korean only SNVs prevalent across many of the individuals would be more important for treating Koreans differently from other populations in the personalized medicine.

Cited from paper[5]


MAF(minor allele frequency) clearly differs from the other ethnic population, includingthe Japanese, the Chinese.

Believe it or not, the variants distribution of Koreans completely differ from The Japanese in spite of same East Asians, and needless to say, differs from other populations too, please see below cited contents.
 
1.Very large scale analyzing of whole exome region clearly indecates that nonsynonymous variants are a half of SNVs in exome region of human and a great majority of SNVs occurred at a minor allele frequency of ≤1%(=0.01).
from paper[2]

2. In the case of The Japanese too, overwhelming majority of of SNVs occurr at a minor allele frequency of ≤1%.
from paper[9]

3. Contrastly, Koreans indecates strange variants distribution.
from paper by FDA


12859_2014_6653_MOESM5_ESM.jpg from paperby FDA




The overwhelming majority of variants which are inherent to Koreans have relation to mental diseases, personality disorders and human mentality.


Gene Name
# of SNV-1 Mental disoreder
Mental traits
neuropsychiatric diseases
CSMD1



1786 schizophrenia
paper[9]
paper[52]
paper[115]
paper[116]
paper[141]
paper[142]
paper[148]
paper[165]
paper[170]

bipolar disorder
paper[66]
paper[148]
paper[165]

general cognitive ability
paper[116]
paper[138]

autism
paper[137

amygdala connectivity and prosocial behavior
paper[139]

Neuropsychological effects
paper[140]

Many other related papers have been released.
RBFOX1

1272 intelligence
paper[168]
paper[169]

insomnia
paper[161]

autism
paper[165]

aggressive behavior
paper[100]

psychiatric disorders and related traits
paper[5]
paper[167]
paper[121]

Aggressiveness, Personality, and Alcohol Use Disorder
paper[122]

Attention Deficit/Hyperactivity Disorder
paper[123]

Aggressive Behavior
paper[124]

schizophrenia
(the neuronspecific RNA splicing regulator)
paper[125]

Many other related papers have been released.

continue.... 
Please visit for details.

Could you understand how unique Koreans genetic architecture is?




Name: Kazuo Ueda (resercher of Korean history)
Country: Japan




I think that we human being should not deny scientific fact, under the name of racism. As a matter of fact, the ironic thing is that the most racist country in the world surely is South Korea, maybe you can't find a Korean female formally married with Blacks. In the event that you find a Korean female formally married with Blacks, please teach me, to my knowledge, it's very few compared with Japanese and Chinese.

I infer that the interaction between Koreans DNA (I. e. genetic factors) and the environment (I. e. sociocultural factors) created very unique society in Korean peninsura.

Researcher of population genetics around the world except for Koreans should read the following paper and analyze the very unique genetic architecture of Koreans DNA like FDA (Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration).

Whole genome sequencing of 35 individuals provides insights into the genetic structure of Korean population
Wenqian Zhang et al.
Published: 21 October 2014



[Citations]
FDA paper
Whole genome sequencing of 35 individuals provides insights into the genetic structure of Korean population
Wenqian Zhang et.al
Published: 21 October 2014

[Cited from the above paper]
In contrast with the SNVs common to other populations in HapMap and 1KGP, the Korean only SNVs had high percentages of non-silent variants, emphasizing the unique roles of these Korean only SNVs in the Korean population. Specifically, we identified 8,361 non-synonymous Korean only SNVs, of which 58 SNVs existed in all 35 Korean individuals.

Based on our analysis, we hypothesize that Koreans might have different responses to the above mentioned terms-related drugs, when compared to other populations.

Therefore, we rationally conjectured that Korean only SNVs prevalent across many of the individuals would be more important for treating Koreans differently from other populations in the personalized medicine.

Therefore, we inferred that special attention should be made for the Korean population when treated for the above mentioned terms related diseases, since other populations did not carry those Korean only SNVs.

According to the SNV compositions (Figure 3), we found that the most prevalent changes in all three SNV sets was C:G->T:A transition, the same trend as the raw base substitution mutational spectrum in humans [42]. In addition, we found that Korean SNVs and SNV-1 occurred more frequently at C/G base pairs, which was consistent with previous findings [42]. Nevertheless, almost half of SNV-35 mutations occurred at T/A base pairs.




paper[1]
Gender, Globalizationand Aesthetic Surgeryin South Korea Ruth Holliday(proffessor in University of Leed and Joanna Elfving-Hwang Curtin University
May 2012

[Cited from the above paper]
This article explores the unusually high levels of cosmetic surgery in South Korea – for both women and men. South Korean’ alleged ‘obsession’ with cosmetic surgery regularly hits headlines both in Asia and the ‘West’ because of its reportedly high take-up rate by both women and men. Cosmetic surgery and skin treatment clinics are now commonplacein urban shopping malls, viewed much like nail and beauty salons in the UK, and providing procedures such as laser removal ofblemishes to 'walk-in’ customers.


paper[2]
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek et.al
Nature 17 August 2016

[Cited from the above paper]
Deleterious variants are expected to have lower allele frequencies than neutral ones, due to negative selection. This theoretical property has been demonstrated previously in human population sequencing data12,13 and here (Fig. 1d, e).


paper[3]
Distribution and clinical impact offunctional variants in 50,726 whole-exomesequences from the DiscovEHR Study
Frederick E. Dewey et.al
Science; accepted 16 November 2016

depth in this study : average 80x


[Cited from the above paper]
The overwhelming majority of these genetic variants occurred at a minor allele frequency of ≤1%, and more than half were singletons.

This abundance of rare variants is consistent with recent accelerated population growth in EuropeanAmerican populations, which comprise an overwhelming majority of the DiscovEHR cohort (fig. S4), and weak purifying selection


paper[4]
Findings of a 1303 Korean whole-exome sequencing study
Soo Heon Kwak et.al
nature; Published: 14 July 2017

depth in this study :

median103.7X


[Cited from the above paper]


paper[5]
A database of 5,305 healthy Korean individuals reveals genetic and clinicalimplications for an East Asian population
Jeongeun Lee et.al
02 November 2022(Nature Genetics)

[Cited from the above paper]



A global reference for human genetic variation The 1000 Genomes Project Consortium
The 1000 Genomes Project Consortium
Nature Published online 2015 Sep 30

[Cited from the above paper]
This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries.




paper[6]
Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population
Sangmoon Lee et.al
Nature Published: 27 June 2017


Functional assessment of nonsynonymous variant supported the presence of purifying selection in Koreans.

depth in this study : 75x
[Cited from the above paper]




paper[7]
Korean Genome Project: 1094 Korean personal genomes with clinical information
Science Advances 27 May 2020
Sungwon Jeon et.al

[Cited from the above paper]


paper[8]
Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
Daniel Taliun et.al
Nature Published: 10 February 2021

depth in this study : average 38x
[Cited from the above paper]
[Among the more than 400 million detected variants, 97% have frequencies of less than 1% and 46% are singletons that are present in only one individual (53% among unrelated individuals). (cited from Abstract)
Here we describe high-coverage whole-genome sequencing (WGS) analyses of the first 53,831 TOPMed samples.
Among all variants, we observed 3.17 million nonsynonymous and 1.53 million synonymous variants (a 2.1:1 ratio), but individual genomes contained similar numbers of nonsynonymous and synonymous variants (11,743 nonsynonymous and 11,768 synonymous, on average) (Extended Data Table 4). The difference can be explained if more than half of the nonsynonymous variants are removed from the population by natural selection before they become common.

paper[9]
Human genetic variation database, a reference database of genetic variations in the Japanese population
Koichiro Higasa et.al
Nature Published: 25 February 2016
depth in this study :at least 10x
[Cited from the above paper]
The allele frequencies for the majority (88.8%) were lower than 0.5% in allele frequency and predicted to be functionally deleterious.





paper[10
Extensive genomic and transcriptional diversity identifiedthrough massively parallel DNA and RNA sequencing of eighteen Korean individuals
Young Seok Ju et.al
2011

[Cited from the above paper]
A subset of the nsSNPs showed remarkably high allele frequencies among the Koreans studied compared to other populations, including Europeans and west Africans represented in the HapMap project.

We found a subset of genes to be highly enriched for nsSNPs, here called super nsSNP genes


paper[11]
Korean National Standard Reference Variome database of whole genomes with comprehensive SNV, indel, CNV, and SV analyses
Nature Published: 04 April 2018
Jungeun Kim et.al

[Cited from the above paper]
Surprisingly, however, roughly half of the variants in ‘1000GP low frequency’ were classified as ‘frequent in KoVariome’.

Despite their close geographic proximity, the Korean population was shown to be genetically distinct from the Chinese and Japanese populations, highlighting the need for a Korean-specific variome to accurately identify rare disease variants in this population.

paper[12]
Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes
Jiang Li et.al
February 2018


[Cited from the above paper]
We also included SCZ risk SNPs identified by the Psychiatric Genomics Consortium using a polygenic risk analysis. The top genomic loci, with uncorrected p < 10− 4, include :
1) synaptic adhesion (PTPRD, LRRC4C, NRXN1, ILIRAPL1, SLITRK1) and scaffolding (MAGI1, MAGI2, NBEA) genes,,both essential for synaptic function;
2) other synaptic plasticity-related genes (NRG1/3 and KALRN);
3) the neuron-specific RNA splicing regulator, RBFOX1;
and 4) ion channel genes, e.g. KCNA10, KCNAB1, KCNK9 and CACNA2D3).
Some genes predicted response for patients with both European and African Ancestries. This is the first evidence from clinical trials that SCZ risk SNPs are related to clinical response to an AAPD.

[References]
Rare coding variants in 10 genes confer substantial risk for schizophrenia.
Singh TJ et.al
Nature. April 6, 2022

continue.... 
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As for the newest [References], please visit here (in japanese), using machine translation tool,

Blog in japanese




The following points are scientific facts of Korean DNA, indecating the uniquness of genetic structure.
1. Unusual high ratio of nonsynonymous variants compared with other population.
2.Strange distribution of minor allele of frequency and of Korean only variants.